Evidence-Based Innovation

Research & publications

Peer-reviewed research, news articles and testimonials highlighting the effectiveness and impact of our technologies in wound closure and infection prevention.

Research & publications

Regional Antibiotic Delivery for Implanted Cardiovascular Electronic Device Infections

Salvage of Infected Cardiac Implantable Electronic Device and Pregnancy Preservation Using CITA-MIS

Continuous in situ targeted antibiotics for late cardiovascular implantable electronic device pocket perforation

In-vitro model for bacterial growth inhibition of compartmentalized infection treated by an ultra-high concentration of antibiotics

Direct Delivery of Antibiotics to CV Device Pocket Infections Appears Promising

Contributions of Israel to the field of clinical cardiac electrophysiology and implantable devices

Safe and Early Primary Closure of Open Abdomen in Pediatric Liver Transplantation Using a Doppler-Guided Tension Relief Strategy and Enhanced Wound Environment

Delayed Abdominal Wall Reconstruction Using the TopClosure® Tension-Relief System: Case Series

Regulated NPWT combined with TopClosure® in treatment of skin defect for open fracture in lower extremity: a case report

Innovative approach to open abdomen: converting an enteroatmospheric fistula into an easily manageable stoma

Minimizing treatment complexity of combat-related soft tissue injuries using a dedicated tension relief system and negative pressure therapy augmented by high-dose in situ antibiotic therapy and oxygen delivery

Case Report: Delayed Primary Wound Closure After Extensive Abdominal Wall Resection for Infection and Malignancy Using TopClosure®

Israeli Innovations in the Field of Plastic Surgery

Pediatric Wound Closure by a Tension-Relief System

The TopClosure® 3S System, for skin stretching and a secure wound closure

A substitute for skin grafts, flaps, or internal tissue expanders in scalp defects following tumor ablative surgery

Stress-Relaxation and Tension Relief System for Immediate Primary Closure of Large and Huge Soft Tissue Defects: An Old-New Concept

Tissue loads applied by a novel medical device for closing large wounds

TopClosure System Adapted to Chelonian Shell Repair

Early Surgical Management of Large Scalp Infantile Hemangioma Using the TopClosure® Tension-Relief System

Delayed primary closure of extensive wounds using the TopClosure system and topical negative pressure therapy

Evaluation of a new tension relief system for securing wound closure: A single-centre, Chinese cohort study

Relaxation systems of the skin for the closure of large mammary defects

The effect of TopClosure® TRS in the treatment of large abdominal wall defect

Simplified management of a giant forehead congenital nevus allows for early reconstruction

Complicated wound closure following mastectomy and breast reconstruction

Secondary closure of open sternal wound using mechanical creep and negative pressure wound therapy in an outpatient setting

TopClosure Tension Relief System for wound closure

Closure of Challenging Pediatric Scalp Wounds by a Tension-Relief System

Application of regulated oxygen-enriched negative pressure-assisted wound therapy in combating anaerobic infections

Improved wound management by regulated negative pressure-assisted wound therapy and regulated, oxygen-enriched negative pressure-assisted wound therapy through basic science research and clinical assessment

"Principles and Practice of Wound Care", Chapter 35 by Dr. Topaz

Treatment of Infected Soft Tissue Blast Injury in Swine by Regulated Negative Pressure Wound Therapy

Electronic book, Orthopedics in Disasters

Improvement of wound healing by regulated oxygen-enriched negative pressure-assisted wound therapy in a rabbit model

Gold nanoparticles for tracking bacteria clearance by regulated irrigation and negative pressure-assisted wound therapy

Tracking bacteria clearance using gold nanoparticles for wound therapy applications

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